Takada Lab - UC Davis
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News 36 Publications 1 Members

Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1...

Mori, S Kodaira, M Ito, A Okazaki, M Kawaguchi, N Hamada, Y Yoshikazu Takada Matsuura, N

Published in PLoS ONE

Epithelial-to-mesenchymal transition (EMT) plays a critical role in cancer metastasis, and is regulated by growth factors such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGF) secreted from the stromal and tumor cells. However, the role of growth factors in EMT has not been fully established. Several integrins are upregul...

Rotavirus spike protein VP5* binds alpha2beta1 integrin on the cell surface and competes with virus for cell binding and...

Graham, Kl Yoshikazu Takada Coulson, Bs

Published in Journal of General Virology

Rotaviruses recognize several cell-surface molecules, including the alpha2beta1 integrin, and the processes of rotavirus cell attachment and entry appear to be multifactorial. The VP5* subunit of the rotavirus spike protein VP4 contains the alpha2beta1 ligand sequence Asp-Gly-Glu at residues 308-310. Binding to alpha2beta1 and infectivity of monkey...

Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1).

Majumdar, M Tarui, T Shi, B Akakura, N Ruf, W Yoshikazu Takada

Published in Journal of Biological Chemistry

Plasmin is a major extracellular protease that elicits intracellular signals to mediate platelet aggregation, chemotaxis of peripheral blood monocytes, and release of arachidonate and leukotriene from several cell types in a G protein-dependent manner. Angiostatin, a fragment of plasmin(ogen), is a ligand and an antagonist for integrin alpha(9)beta...

An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antago...

Fujita, M Ieguchi, K Cedano-Prieto, Dm Fong, A Wilkerson, C Chen, Jq Wu, M Lo, Sh Cheung, At Wilson, Md ...

Published in Journal of Biological Chemistry

Insulin-like growth factor-1 (IGF1) is a major therapeutic target for cancer. We recently reported that IGF1 directly binds to integrins (αvβ3 and α6β4) and induces ternary complex formation (integrin-IGF1-IGF1 receptor (IGF1R)) and that the integrin binding-defective mutant of IGF1 (R36E/R37E) is defective in signaling and ternary complex formatio...

Optimization of RGD-Containing Cyclic Peptides against αvβ3 Integrin.

Wang, Y Xiao, W Zhang, Y Meza, L Tseng, H Yoshikazu Takada Ames, Jb Lam, Ks

Published in Molecular Cancer Therapeutics

We have previously reported the use of one-bead-one-compound (OBOC) combinatorial technology to develop a disulfide cyclic, Arg-Gly-Asp-containing octapeptide LXW7 (cGRGDdvc), that targets αvβ3 integrin with high affinity and specificity. αvβ3 integrin is known to be overexpressed in many cancers and in tumor vasculature, and it has been establishe...

The integrins.

Yoshikazu Takada Ye, X Simon, S

Published in Genome Biology

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane alphabeta heterodimers and at least 18 alpha and eight beta subunits are known in humans, generating 24 heterodimers. Members of this family have been found in mammals, chicken and z...

ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.

Thodeti, Ck Fröhlich, C Nielsen, Ck Yoshikazu Takada Fässler, R Albrechtsen, R Wewer, Um

Published in FEBS Letters

ADAM12, adisintegrin and metalloprotease, has been demonstrated to be upregulated in human malignant tumors and to accelerate the malignant phenotype in a mouse model for breast cancer. ADAM12 is a substrate for beta1 integrins and may affect tumor and stromal cell behavior through its binding to beta1 integrins. Here, we report that cells deficien...

Cross-talk between integrin α6β4 and insulin-like growth factor-1 receptor (IGF1R) through direct α6β4 binding to IGF1 a...

Fujita, M Ieguchi, K Davari, P Yamaji, S Taniguchi, Y Sekiguchi, K Takada, Yk Yoshikazu Takada

Published in Journal of Biological Chemistry

Integrin αvβ3 plays a role in insulin-like growth factor-1 (IGF1) signaling (integrin-IGF1 receptor (IGF1R) cross-talk). The specifics of the cross-talk are, however, unclear. In a current model, "ligand occupancy" of αvβ3 (i.e. the binding of extracellular matrix proteins) enhances signaling induced by IGF1 binding to IGF1R. We recently reported t...

Inhibition of tissue factor signaling suppresses tumor growth.

Versteeg, Hh Schaffner, F Kerver, M Petersen, Hh Ahamed, J Felding-Habermann, B Yoshikazu Takada Mueller, Bm Ruf, W

Published in Blood

Coagulation activation by tissue factor (TF) is implicated in cancer progression, cancer-associated thrombosis and metastasis. The role of direct TF signaling pathways in cancer, however, remains incompletely understood. Here we address how TF contributes to primary tumor growth by using a unique pair of isotype-matched antibodies that inhibit eith...

Non-cytotoxic cobra cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption. Identification of cardi...

Wu, Pl Lee, Sc Chuang, Cc Mori, S Akakura, N Wu, Wg Yoshikazu Takada

Published in Journal of Biological Chemistry

Severe tissue necrosis with a retarded wound healing process is a major symptom of a cobra snakebite. Cardiotoxins (CTXs) are major components of cobra venoms that belong to the Ly-6 protein family and are implicated in tissue damage. The interaction of the major CTX from Taiwan cobra, i.e. CTX A3, with sulfatides in the cell membrane has recently ...

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