Takada Lab - UC Davis
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News 36 Publications 1 Members

Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces prolifer...

Saegusa, Jun Akakura, Nobuaki Wu, Chun-Yi Hoogland, Case Ma, Zi Lam, Kit S Liu, Fu-Tong Takada, Yoko K Takada, Yoshikazu

Published in The Journal of biological chemistry

Secretory phospholipase A2 group IIA (sPLA2-IIA) plays an important role in the pathogenesis of inflammatory diseases. Catalytic activity of this enzyme that generates arachidonic acid is a major target for development of anti-inflammatory agents. Independent of its catalytic activity, sPLA2-IIA induces pro-inflammatory signals in a receptor-mediat...

The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action....

Fujita, M Takada, Yk Izumiya, Y Yoshikazu Takada

Published in PLoS ONE

The prototypic acute phase reactant C-reactive protein (CRP) is not only a marker but also a potential contributor to inflammatory diseases. CRP exists as the circulating native, pentameric CRP (pCRP) and the monomeric isoform (mCRP), formed as a result of a dissociation process of pCRP. mCRP is highly pro-inflammatory, but pCRP is not. The mechani...

Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin αvβ3.

Ye, L Dickerson, T Kaur, H Takada, Yk Fujita, M Liu, R Knapp, Jm Lam, Ks Schore, Ne Kurth, Mj ...

Published in Bioorganic & Medicinal Chemistry Letters

Increased concentrations of secreted phospholipase A2 type IIA (sPLA2-IIA), have been found in the synovial fluid of patients with rheumatoid arthritis. It has been shown that sPLA2-IIA specifically binds to integrin αvβ3, and initiates a signaling pathway that leads to cell proliferation and inflammation. Therefore, the interaction between integri...

Novel peptide ligands for integrin alpha 4 beta 1 overexpressed in cancer cells.

Mikawa, M Wang, H Guo, L Liu, R Marik, J Yoshikazu Takada Lam, K Lau, D

Published in Molecular Cancer Therapeutics

Using the "one-bead one-peptide" combinatorial technology, a library of random cyclic octapeptides and nonapeptides, consisting of natural and unnatural amino acids, was synthesized on polystyrene beads. This library was used to screen for peptides that promoted attachment and proliferation of bronchioloalveolar carcinoma cells (H1650), employing a...

Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging....

Peng, L Liu, R Marik, J Wang, X Yoshikazu Takada Lam, Ks

Published in Nature Chemical Biology

Small peptide-based agents have attracted wide interest as cancer-targeting agents for diagnostic imaging and targeted therapy. There is a need to develop new high-affinity and high-specificity peptidomimetic or small-molecule ligands against cancer cell surface receptors. Here we report on the identification of a high-affinity peptidomimetic ligan...

Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is ...

Fujita, M Takada, Yk Yoshikazu Takada

Published in The Journal of Immunology

The membrane-bound chemokine fractalkine (FKN, CX3CL1) on endothelial cells plays a role in leukocyte trafficking. The chemokine domain (FKN-CD) is sufficient for inducing FKN signaling (e.g., integrin activation), and FKN-CD binds to its receptor CX3CR1 on leukocytes. Whereas previous studies suggest that FKN-CD does not directly bind to integrins...

Rotavirus-neutralizing antibodies inhibit virus binding to integrins alpha 2 beta 1 and alpha 4 beta 1.

Fleming, Fe Graham, Kl Taniguchi, K Yoshikazu Takada Coulson, Bs

Published in Archives of Virology

Rotavirus outer capsid proteins VP5(*), VP8(*) and VP7 elicit neutralizing, protective antibodies. The alpha 2 beta 1 integrin is a cellular receptor for rotavirus that is bound by VP5(*). Some rotaviruses also recognize the alpha 4 beta 1 integrin. In this study, the effects of antibodies to rotavirus on virus binding to recombinant alpha 2 beta 1...

Rotaviruses interact with alpha4beta7 and alpha4beta1 integrins by binding the same integrin domains as natural ligands....

Graham, Kl Fleming, Fe Halasz, P Hewish, Mj Nagesha, Hs Holmes, Ih Yoshikazu Takada Coulson, Bs

Published in Journal of General Virology

Group A rotaviruses are major intestinal pathogens that express potential alpha4beta1 and alpha4beta7 integrin ligand sequences Leu-Asp-Val and Leu-Asp-Ile in their outer capsid protein VP7, and Ile-Asp-Ala in their spike protein VP4. Monkey rotavirus SA11 can use recombinant alpha4beta1 as a cellular receptor. In this study a new potential alpha4b...

A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist.

Yamaji, S Saegusa, J Ieguchi, K Fujita, M Mori, S Takada, Yk Yoshikazu Takada

Published in PLoS ONE

Galectin-3 modulates phagocytosis-induced stellate cell activation and liver fibrosis in vivo.

Jiang, Jx Chen, X Hsu, Dk Baghy, K Serizawa, N Scott, F Yoshikazu Takada Takada, Y Fukada, H Chen, J ...

Published in AJP Gastrointestinal and Liver Physiology

Hepatic stellate cells (HSC), the key fibrogenic cells of the liver, transdifferentiate into myofibroblasts upon phagocytosis of apoptotic hepatocytes. Galectin-3, a β-galactoside-binding lectin, is a regulator of the phagocytic process. In this study, our aim was to study the mechanism by which extracellular galectin-3 modulates HSC phagocytosis a...

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